PhD Student position in Medical Science –Clinical Pharmacology, Uppsala University, Sweden at the Department of Medical Sciences, Uppsala University Hospital.
The research project focus on preclinical models for the identification and characterization of potentially new cancer drugs, especially targeting colorectal cancer (CRC). Cell line models of CRC, genetically modified for signal pathways known to be aberrantly expressed in CRC will be screened for cytotoxic activity of molecules in large chemical libraries. Screening hits will then be further characterized in more clinically relevant tumour models of tumour cell spheroids and tumour cells from patients, followed by mechanistic characterization based on eg analysis of gene expression patterns. Candidate drugs will then be investigated in vivo in tumour bearing animals, hopefully followed by clinical testing in collaboration with drug companies.
The applicant should have comprehensive medical knowledge at the preclinical and clinical level to be able to understand and perform the project and to, in relation to the project group in total, represent a clinical perspective. The applicant is also in need of documented experience of preclinical techniques basic to the project, notably tumour cell culture and measurement of cellular cytotoxicity. Since the project will include tumour samples from patients, the applicant has to be able to read and understand patient files and pathology reports to extract relevant clinical data.
Previous experience in experimental research is a merit. Skills in oral and written english is necessary. The application should include a curriculum vitae, copies of exams, degrees and grades, a copy of your Master thesis (or a draft thereof), references, a short description of the applicant and his/her experience. Letter(s) of recommendation may be included.
For more information, please contact: prof Peter Nygren, phone +4418- 611 49 41, e-mail: peter.nygren@medsci.uu.se or Anna Foyer, personal coordinator, phone +4618-611 43 92, anna.foyer@medsci.uu.se.
Union representatives are Anders Grundström, Saco, +46 (0)18-471 5380, Carin Söderhäll, TCO/ST, +46 (0)18-471 1996 and Stefan Djurström Seko, +46 (0)18-471 3315.
The application should be sent, preferrably by e-mail to: registrator@uu.se, or by fax +46-184712000, or by mail to: Registrar’s Office, Uppsala University, Box 256, SE-751 05 UPPSALA, Sweden. In any correspondence, please use the reference number UFV-PA 2010/2065. Application deadline on 23 August, 2010.
Further Scholarships College details:
http://www.personalavd.uu.se/ledigaplatser/2065dorand_eng.htm
Scholarships for PhD Student in Medical Science –Clinical Pharmacology, Uppsala University, Sweden
